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dc.creatorCardoso, Francisco das Chagas Pereira-
dc.creator.Latteshttp://lattes.cnpq.br/3764704363281886por
dc.contributor.advisor1Almeida, Pedro Marcos de-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/4917070654832103por
dc.contributor.advisor-co1Freitas, Samya Danielle Lima de-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/7961603023838547por
dc.contributor.referee1Almeida, Pedro Marcos de-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/4917070654832103por
dc.contributor.referee2Freitas, Samya Danielle Lima de-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/7961603023838547por
dc.contributor.referee3Souza, João Sammy Nery de-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/9712456150235877por
dc.contributor.referee4Castro, Ícaro Fillipe de Araújo-
dc.contributor.referee4Latteshttp://lattes.cnpq.br/0758573905655441por
dc.date.accessioned2026-01-15T12:23:24Z-
dc.date.issued2025-
dc.identifier.citationCARDOSO, Francisco das Chagas Pereira. Prospecção fitoquímica e efeito genoprotetor das cascas da Poincianella bracteosa (TUL.) L.P. Queiroz em células meristemáticas de Allium cepa (L.). 2025. 73 f. Dissertação (Programa de Pós-Graduação em Química) - Universidade Estadual do Piauí, Teresina, 2025.por
dc.identifier.urihttp://sistemas2.uespi.br/handle/tede/3111-
dc.description.resumoPoincianella bracteosa (Fabaceae), conhecida como catingueira, tem uso popular no tratamento de diarreias, hepatite, infecções e enxaqueca. O presente trabalho teve como objetivo caracterizar o perfil fitoquímico, atividade antioxidante, citogenotóxica e efeito genoprotetor do extrato etanólico (EE) das cascas do caule de P. bracteosa em células meristemáticas de Allium cepa. A prospecção química qualitativa e cromatografia em camada delgada (CCD) do EE detectaram fenóis, saponinas, alcaloides, flavonoides, taninos pirogálicos e terpenos, enquanto a HPLC-DAD mostrou flavonoides e ácidos fenólicos. A caracterização metabólica por Orbitrap-HRMS ESI (-) do EE sugeriu a presença de compostos evidenciados pela primeira vez na espécie, como o kaempferol, quercertina, isoquercitrina, isovitexina, ácidos (ursólico, gálico, dicafeoilquínico, elágico), amentoflavona, castalagina e corilagina. O EE demonstrou atividade antioxidante frente ao radical DPPH (CE50 = 27,53 ± 0,26 μg/ml) e ABTS (CE50 = 122,81 ± 2,03 μg/ml) e o teor de compostos fenólicos foi de 225,53 mg EAG/g. No ensaio A. cepa, o EE apresentou citotoxicidade nas duas maiores concentrações (1 e 2 mg/ml), não foi genotóxico em nenhuma das concentrações (0,25; 0,5; 1 e 2 mg/ml) e demonstrou efeito genoprotetor no pré, simultâneo e pós-tratamento com porcentagem de redução variando de 49,79 a 52,28 (pré); 65,17 a 93,70 (simultâneo) e 49,50 a 86,66 (pós). Os resultados mostraram que o EE é fonte importante de compostos antioxidantes com efeito não genotóxico e genoprotetor, sugerindo aplicações terapêuticas, especialmente em doenças relacionadas ao estresse oxidativo.por
dc.description.abstractPoincianella bracteosa (Fabaceae), known as catingueira, is commonly used to treat diarrhea, hepatitis, infections, and migraines. This study aimed to characterize the phytochemical profile, antioxidant activity, cytotoxicity, and genoprotective effects of the ethanolic extract (EE) from the stem bark of P. bracteosa on meristematic cells of Allium cepa. Qualitative chemical prospecting and thin-layer chromatography (TLC) of the EE detected phenols, saponins, alkaloids, flavonoids, pyrogallic tannins, and terpenes, while HPLC-DAD revealed flavonoids and phenolic acids. Metabolic characterization using Orbitrap-HRMS ESI (-) of EE suggested the presence of compounds, such as kaempferol, quercetin, isoquercitrin, isovitexin, acids (ursolic, gallic, dicaffeoyl quinic, and ellagic), amentoflavone, castalagin, and corilagin, which have been evidenced for the first time in this species. EE exhibited antioxidant activity against DPPH (EC50 = 27.53 ± 0.26 μg/ml) and ABTS (EC50 = 122.81 ± 2.03 μg/ml) radicals, with a phenolic compound content of 225.53 mg EAG/g. In the A. cepa assay, EE showed cytotoxicity at the two highest concentrations (1 and 2 mg/ml), was not genotoxic at any of the concentrations (0.25, 0.5, 1, and 2 mg/ml), and demonstrated a genoprotective effect in pre-, simultaneous, and post-treatment, with percentage reduction ranging from 49.79 to 52.28 (pre), 65.17 to 93.70 (simultaneous), and 49.50 to 86.66 (post). The results showed that EE is an important source of antioxidant compounds with non-genotoxic and genoprotective effects, suggesting its therapeutic applications, especially in diseases related to oxidative stress.eng
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dc.languageporpor
dc.publisherUniversidade Estadual do Piauípor
dc.publisher.departmentCentro de Ciencias da Naturezapor
dc.publisher.countryBrasilpor
dc.publisher.initialsUESPIpor
dc.publisher.programPrograma de Pós-Graduação em Químicapor
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Phytochemical Profile and Evaluation of the Antioxidant, Cyto-Genotoxic, and Antigenotoxic Potential of Salvia verticillata Hydromethanolic Extract. Plants, v. 13, n. 5, p. 731, 5 mar. 2024.por
dc.rightsAcesso Abertopor
dc.subjectAlterações Cromossômicaspor
dc.subjectAtividade Antioxidanteeng
dc.subjectCatingueirapor
dc.subjectPolifenóispor
dc.subject.cnpqCIENCIAS EXATAS E DA TERRA::QUIMICApor
dc.titleProspecção fitoquímica e efeito genoprotetor das cascas da Poincianella bracteosa (TUL.) L.P. Queiroz em células meristemáticas de Allium cepa (L.)por
dc.title.alternativePhytochemical prospecting and genoprotective effect of Poicianella bracteosa (TUL.) L.P. Queiroz bark on meristematic cells of Allium cepa (L)por
dc.typeDissertaçãopor
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